Cisplatin-induced apoptosis is reduced in cisplatin resistant cell lines.

<p>Parent and resistant cell lines were treated with cisplatin for 72 h. Apoptotic cells, as measured by the percentage cells in the SubG0 phase of the cell cycle, were measured. Levels of apoptosis induced by cisplatin were significantly increased in parent cells while cisplatin-induced apoptosis was significantly reduced in the corresponding resistant cell line. Data are expressed as Mean ± SEM from three independent experiments (n = 3) (*p<0.01 vs PT untreated, **p<0.001 vs PT untreated, ^$$p<0.001 vs CisR untreated, ^$p<0.01 vs CisR untreated [A549, H460], ^$p<0.05 vs CisR untreated [MOR], ^$p<0.05 PT vs CisR, ^#p<0.001 PT vs CisR, *^$p<0.05 vs PT untreated).