Doxorubicin decreases AQP2 in inner medulla (IM) and Erlotinib restores levels in IM tip.

<p>Shown: AQP2 protein abundance in IM tip and base tissue of control rats (<i>Ctrl</i>; white bars), doxorubicin treated rats (<i>Dox</i>; solid black bars), and doxorubicin + Erlotinib treated rats (<i>Dox + Erl</i>; patterned bars). <b>A</b>: Representative immunoblots showing abundance of AQP2 in IM tip and base tissue lysates. Each lane containes samples from a different rat. <b>B</b>: Densitometric analysis of western blots from 3 cohorts of animals. Data were normalized for the average densitometry of untreated animals in each group. Data are expressed as means ± SE (n = 11, * p<0.05).