Cisplatin resistant cells accumulate in the G0/G1 phase of the cell cycle.

<p>Parent and Cisplatin resistant NSCLC cells were treated with cisplatin for 24 h. Cell cycle distribution of PT and CisR cells was examined by propidium iodide staining and measured by FACS (A). A significant accumulation of CisR cells was observed in the G0/G1 phase of the cell cycle across the panel of cell lines. Representative histograms showing cell cycle distribution of SKMES-1 CisR cells and PT counterparts in response to increasing concentrations of cisplatin are shown (B). Data are expressed as Mean ± SEM from three independent experiments (n = 3) (^#p<0.001, ^*p<0.05).