Graphical illustration summarizing the proposed mechanism underlying TWEAK-induced cardiac dysfunction.
- Jianru Shi (288305)
- Bingbing Jiang (288306)
- Yiling Qiu (115394)
- Jian Guan (288307)
- Mohit Jain (38715)
- Xin Cao (288308)
- Michael Bauer (115390)
- Lihe Su (46634)
- Linda C. Burkly (46637)
- Teresa C. Leone (106935)
- Daniel P. Kelly (106939)
- Ronglih Liao (115411)
Publication date
February 2013
DOIAbstract
<p>Normal PGC1 levels maintain OXPHOS gene expression and mitochodrial function to support cardiomyocyte contractility (left panel). TWEAK downregulates PGC1 levels through FN14-TRAF2-NFκB-dependent signaling, leading to impaired OXPHOS gene expression and mitochondrial dysfunction, and reduced cardiomyocyte contractility (right panel).</p
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