In vitro anti-leishmanial activity of TPM compounds expressed as IC50 (µM) on promastigotes assay.

In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195

Carlos Eduardo Sampaio Guedes
Beatriz Rocha Simões Dias
Antonio Luis de Oliveira Almeida Petersen
Kercia Pinheiro Cruz
Niara de Jesus Almeida
Daniela Rodrigues Andrade
Juliana Perrone Bezerra de Menezes
Valéria de Matos Borges
Patricia Sampaio Tavares Veras

February 2018

BACKGROUND Leishmaniasis, one of the most neglected diseases, is a serious public health problem in ...

In vitro assays of axenic amastigotes from Leishmania amazonensis with oxoisoaporphine derivatives 1–18.

Eduardo Sobarzo-Sánchez (477516)
Pablo Bilbao-Ramos (477517)
Maria Dea-Ayuela (477518)
Humberto González-Díaz (477519)
Matilde Yañez (477520)
Eugenio Uriarte (148778)
Lourdes Santana (148774)
Victoria Martínez-Sernández (340051)
Francisco Bolás-Fernández (477521)
Florencio M. Ubeira (340062)

October 2013

IC90: 90% inhibitory concentration, IC50: 50% inhibitory concentration.</p

In vitro growth inhibitory activity of Medicines for Malaria Venture pathogen box compounds against Leishmania aethiopica

Markos Tadele
Solomon M. Abay
Peter Asaga
Eyasu Makonnen
Asrat Hailu

November 2021

Abstract Introduction Leishmania aethiopica (L. aethiopica) is responsible for different forms of cu...

Cytotoxicity, anti-leishmanial in vitro activity and selectivity index (SI) of TPM 1, TPM 2, TPM 6, TPM 9 and GV against L. (L.) amazonensis and L. (V.) braziliensis on intracellular amastigotes assay.

Renata Celi Carvalho de Souza Pietra (288729)
Lucas Fonseca Rodrigues (288733)
Eliane Teixeira (288737)
Levi Fried (288741)
Benjamin Lefkove (288744)
Ana Rabello (112015)
Jack Arbiser (230839)
Lucas Antônio Miranda Ferreira (288749)
Ana Paula Fernandes (4220)

February 2013

IC50 values correspond to mean and 95% CI of results obtained from triplicates; n.d., ...

Inhibition of Leishmania promastigotes grown by cordilin, psilostachyin, cumanin and daucosterol.

Valeria P. Sülsen (469415)
Silvia I. Cazorla (368621)
Fernanda M. Frank (252111)
Laura C. Laurella (469416)
Liliana V. Muschietti (469417)
Cesar A. Catalán (469418)
Virginia S. Martino (469419)
Emilio L. Malchiodi (368622)

October 2013

Promastigotes of (A) L. amazonensis and (B) L. braziliensis, were adj...

In vitro anti-leishmanial activity and cytotoxicity results for trans-Resveratrol Analogs.

Carlos Luan Alves Passos (820231)
Christian Ferreira (820232)
Deivid Costa Soares (308670)
Elvira Maria Saraiva (263417)

October 2015

* The selectivity index (SI) was calculated as the ratio of CC50 on murine peritoneal ...

Inhibition percentage of promastigote and axenic amastigote forms of Leishmania amazonensis treated with BenzCo for 72 h in culture.

Elizandra Aparecida Britta (313002)
Ana Paula Barbosa Silva (313003)
Tânia Ueda-Nakamura (313004)
Benedito Prado Dias-Filho (313005)
Cleuza Conceição Silva (313006)
Rosana Lázara Sernaglia (313007)
Celso Vataru Nakamura (313008)

February 2013

The data are expressed as the means from three independent tests. All of the results were statist...

Leishmanicidal activity on L. braziliensis promastigotes of mikanolide, dihidromikanolide, deoxymikanolide and scandenolide.

Laura C. Laurella (469416)
Natacha Cerny (4458595)
Augusto E. Bivona (4458598)
Andrés Sánchez Alberti (4458604)
Gustavo Giberti (4458592)
Emilio L. Malchiodi (368622)
Virginia S. Martino (469419)
Cesar A. Catalan (4458607)
María Rosario Alonso (4458601)
Silvia I. Cazorla (368621)
Valeria P. Sülsen (469415)

September 2017

Parasites were cultured for 72 h in the presence of the compounds (0–50 μg/mL). Growth inhibition...

In vivo antileishmanial efficacy of miltefosine against Leishmania (Leishmania) amazonensis

Garcia Bustos, Maria Fernanda
Barrio, Alejandra
Prieto, Gabriela G.
De Raspi, Emma M.
Cimino, Rubén Oscar
Cardozo, Rubén Marino
Parada, Luis Antonio
Yeo, Matthew
Soto, Jaime
Uncos, Delfor Alejandro
Parodi Ramoneda, Cecilia María
Basombrío, Miguel Ángel Manuel

December 2014

Leishmaniasis, a disease caused by parasites of the Leishmania genus, constitutes a significant heal...

Novel 2D and 3D Assays to Determine the Activity of Anti-Leishmanial Drugs

O’Keeffe, A
Hale, C
Cotton, JA
Yardley, V
Gupta, K
Ananthanarayanan, A
Murdan, S
Croft, SL

June 2020

The discovery of novel anti-leishmanial compounds remains essential as current treatments have known...

Novel 2D and 3D assays to determine the activity of anti-leishmanial drugs

O’Keeffe, Alec
Hale, Christine
Cotton, James A.
Yardley, Vanessa
Gupta, Kapish
Ananthanarayanan, Abhishek
Murdan, Sudaxshina
Croft, Simon L.

June 2020

The discovery of novel anti-leishmanial compounds remains essential as current treatments have known...

Experimental Parasitology

Mehta, Sanjay R.
Xing, Quan Zhang
Badaro, Roberto
Spina, Celsa
Day, John
Kwang, Poo Chang
Schooley, Robert T.

January 2013

Texto completo: acesso restrito. p.617–620High-throughput drug screening methods against the intrace...

Effective Tetradentate Compound Complexes against Leishmania spp. that Act on Critical Enzymatic Pathways of These Parasites

Urbanová, Kristína
Ramírez Macías, Inmaculada
Martín-Escolano, Rubén
Rosales Lombardo, María José
Cussó, Olaf
Serrano, Joan
Company, Anna
Sánchez-Moreno, Manuel
Costas, Miquel
Ribas, Xavi
Marín Sánchez, Clotilde

December 2018

The spectrum and efficacy of available antileishmanial drugs is limited. In the present work we eva...

In vitro and in vivo activity of meglumine antimoniate produced at Farmanguinhos-Fiocruz, Brazil, against Leishmania (Leishmania) amazonensis, L (L.) chagasiand L (Viannia) braziliensis

Morais Teixeira, Eliane de
Carvalho, Alcione S de
Costa, Jorge CS da
Duarte, Silvio L
Mendon??a, Jorge S
Boechat, N??bia
Rabello, Ana

January 2008

The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fioc...

In vitro and in vivo activity of meglumine antimoniate produced at Farmanguinhos-Fiocruz, Brazil, against Leishmania (Leishmania) amazonensis, L (L.) chagasi and L (Viannia) braziliensis

Eliane de Morais-Teixeira
Alcione S de Carvalho
Jorge CS da Costa
Silvio L Duarte
Jorge S Mendonça
Núbia Boechat
Ana Rabello

June 2008

The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fioc...

In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195

Carlos Eduardo Sampaio Guedes
Beatriz Rocha Simões Dias
Antonio Luis de Oliveira Almeida Petersen
Kercia Pinheiro Cruz
Niara de Jesus Almeida
Daniela Rodrigues Andrade
Juliana Perrone Bezerra de Menezes
Valéria de Matos Borges
Patricia Sampaio Tavares Veras

February 2018

BACKGROUND Leishmaniasis, one of the most neglected diseases, is a serious public health problem in ...

In vitro assays of axenic amastigotes from Leishmania amazonensis with oxoisoaporphine derivatives 1–18.

Eduardo Sobarzo-Sánchez (477516)
Pablo Bilbao-Ramos (477517)
Maria Dea-Ayuela (477518)
Humberto González-Díaz (477519)
Matilde Yañez (477520)
Eugenio Uriarte (148778)
Lourdes Santana (148774)
Victoria Martínez-Sernández (340051)
Francisco Bolás-Fernández (477521)
Florencio M. Ubeira (340062)

October 2013

IC90: 90% inhibitory concentration, IC50: 50% inhibitory concentration.</p

In vitro growth inhibitory activity of Medicines for Malaria Venture pathogen box compounds against Leishmania aethiopica

Markos Tadele
Solomon M. Abay
Peter Asaga
Eyasu Makonnen
Asrat Hailu

November 2021

Abstract Introduction Leishmania aethiopica (L. aethiopica) is responsible for different forms of cu...

Cytotoxicity, anti-leishmanial in vitro activity and selectivity index (SI) of TPM 1, TPM 2, TPM 6, TPM 9 and GV against L. (L.) amazonensis and L. (V.) braziliensis on intracellular amastigotes assay.

Renata Celi Carvalho de Souza Pietra (288729)
Lucas Fonseca Rodrigues (288733)
Eliane Teixeira (288737)
Levi Fried (288741)
Benjamin Lefkove (288744)
Ana Rabello (112015)
Jack Arbiser (230839)
Lucas Antônio Miranda Ferreira (288749)
Ana Paula Fernandes (4220)

February 2013

IC50 values correspond to mean and 95% CI of results obtained from triplicates; n.d., ...

Inhibition of Leishmania promastigotes grown by cordilin, psilostachyin, cumanin and daucosterol.

Valeria P. Sülsen (469415)
Silvia I. Cazorla (368621)
Fernanda M. Frank (252111)
Laura C. Laurella (469416)
Liliana V. Muschietti (469417)
Cesar A. Catalán (469418)
Virginia S. Martino (469419)
Emilio L. Malchiodi (368622)

October 2013

Promastigotes of (A) L. amazonensis and (B) L. braziliensis, were adj...

In vitro anti-leishmanial activity and cytotoxicity results for trans-Resveratrol Analogs.

Carlos Luan Alves Passos (820231)
Christian Ferreira (820232)
Deivid Costa Soares (308670)
Elvira Maria Saraiva (263417)

October 2015

* The selectivity index (SI) was calculated as the ratio of CC50 on murine peritoneal ...

Inhibition percentage of promastigote and axenic amastigote forms of Leishmania amazonensis treated with BenzCo for 72 h in culture.

Elizandra Aparecida Britta (313002)
Ana Paula Barbosa Silva (313003)
Tânia Ueda-Nakamura (313004)
Benedito Prado Dias-Filho (313005)
Cleuza Conceição Silva (313006)
Rosana Lázara Sernaglia (313007)
Celso Vataru Nakamura (313008)

February 2013

The data are expressed as the means from three independent tests. All of the results were statist...

Leishmanicidal activity on L. braziliensis promastigotes of mikanolide, dihidromikanolide, deoxymikanolide and scandenolide.

Laura C. Laurella (469416)
Natacha Cerny (4458595)
Augusto E. Bivona (4458598)
Andrés Sánchez Alberti (4458604)
Gustavo Giberti (4458592)
Emilio L. Malchiodi (368622)
Virginia S. Martino (469419)
Cesar A. Catalan (4458607)
María Rosario Alonso (4458601)
Silvia I. Cazorla (368621)
Valeria P. Sülsen (469415)

September 2017

Parasites were cultured for 72 h in the presence of the compounds (0–50 μg/mL). Growth inhibition...

In vivo antileishmanial efficacy of miltefosine against Leishmania (Leishmania) amazonensis

Garcia Bustos, Maria Fernanda
Barrio, Alejandra
Prieto, Gabriela G.
De Raspi, Emma M.
Cimino, Rubén Oscar
Cardozo, Rubén Marino
Parada, Luis Antonio
Yeo, Matthew
Soto, Jaime
Uncos, Delfor Alejandro
Parodi Ramoneda, Cecilia María
Basombrío, Miguel Ángel Manuel

December 2014

Leishmaniasis, a disease caused by parasites of the Leishmania genus, constitutes a significant heal...

Novel 2D and 3D Assays to Determine the Activity of Anti-Leishmanial Drugs

O’Keeffe, A
Hale, C
Cotton, JA
Yardley, V
Gupta, K
Ananthanarayanan, A
Murdan, S
Croft, SL

June 2020

The discovery of novel anti-leishmanial compounds remains essential as current treatments have known...

Novel 2D and 3D assays to determine the activity of anti-leishmanial drugs

O’Keeffe, Alec
Hale, Christine
Cotton, James A.
Yardley, Vanessa
Gupta, Kapish
Ananthanarayanan, Abhishek
Murdan, Sudaxshina
Croft, Simon L.

June 2020

The discovery of novel anti-leishmanial compounds remains essential as current treatments have known...

Experimental Parasitology

Mehta, Sanjay R.
Xing, Quan Zhang
Badaro, Roberto
Spina, Celsa
Day, John
Kwang, Poo Chang
Schooley, Robert T.

January 2013

Texto completo: acesso restrito. p.617–620High-throughput drug screening methods against the intrace...

Effective Tetradentate Compound Complexes against Leishmania spp. that Act on Critical Enzymatic Pathways of These Parasites

Urbanová, Kristína
Ramírez Macías, Inmaculada
Martín-Escolano, Rubén
Rosales Lombardo, María José
Cussó, Olaf
Serrano, Joan
Company, Anna
Sánchez-Moreno, Manuel
Costas, Miquel
Ribas, Xavi
Marín Sánchez, Clotilde

December 2018

The spectrum and efficacy of available antileishmanial drugs is limited. In the present work we eva...

In vitro and in vivo activity of meglumine antimoniate produced at Farmanguinhos-Fiocruz, Brazil, against Leishmania (Leishmania) amazonensis, L (L.) chagasiand L (Viannia) braziliensis

Morais Teixeira, Eliane de
Carvalho, Alcione S de
Costa, Jorge CS da
Duarte, Silvio L
Mendon??a, Jorge S
Boechat, N??bia
Rabello, Ana

January 2008

The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fioc...

In vitro and in vivo activity of meglumine antimoniate produced at Farmanguinhos-Fiocruz, Brazil, against Leishmania (Leishmania) amazonensis, L (L.) chagasi and L (Viannia) braziliensis

Eliane de Morais-Teixeira
Alcione S de Carvalho
Jorge CS da Costa
Silvio L Duarte
Jorge S Mendonça
Núbia Boechat
Ana Rabello

June 2008

The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fioc...

In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195

Carlos Eduardo Sampaio Guedes
Beatriz Rocha Simões Dias
Antonio Luis de Oliveira Almeida Petersen
Kercia Pinheiro Cruz
Niara de Jesus Almeida
Daniela Rodrigues Andrade
Juliana Perrone Bezerra de Menezes
Valéria de Matos Borges
Patricia Sampaio Tavares Veras

February 2018

BACKGROUND Leishmaniasis, one of the most neglected diseases, is a serious public health problem in ...

In vitro assays of axenic amastigotes from Leishmania amazonensis with oxoisoaporphine derivatives 1–18.

Eduardo Sobarzo-Sánchez (477516)
Pablo Bilbao-Ramos (477517)
Maria Dea-Ayuela (477518)
Humberto González-Díaz (477519)
Matilde Yañez (477520)
Eugenio Uriarte (148778)
Lourdes Santana (148774)
Victoria Martínez-Sernández (340051)
Francisco Bolás-Fernández (477521)
Florencio M. Ubeira (340062)

October 2013

IC90: 90% inhibitory concentration, IC50: 50% inhibitory concentration.</p

In vitro growth inhibitory activity of Medicines for Malaria Venture pathogen box compounds against Leishmania aethiopica

Markos Tadele
Solomon M. Abay
Peter Asaga
Eyasu Makonnen
Asrat Hailu

November 2021

Abstract Introduction Leishmania aethiopica (L. aethiopica) is responsible for different forms of cu...

<i>In vitro</i> anti-leishmanial activity of TPM compounds expressed as IC<sub>50</sub> (µM) on promastigotes assay.

Abstract

Extracted data

<i>In vitro</i> anti-leishmanial activity of TPM compounds expressed as IC<sub>50</sub> (µM) on promastigotes assay.

Abstract

Extracted data

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