Behavioral profile of zebrafish larvae to AEDs.

<p>(A) The top graph depicts the average larval locomotor activity within 30 minutes (y-axis) relative to VHC+PTZ (PTZ) control, as depicted by the average % ± SEM; treatment groups where average movement was significantly decreased compared to PTZ (one-way ANOVA) are marked *, **, and *** (p<0.05, p<0.01, and p<0.001, respectively). (B-O) The average total movement (y-axis) of larvae treated with VHC only or PTZ with either VHC or AEDs. The average larval movement is depicted per 5 min interval (x-axis) of the tracking session. Time points when the average movement was significantly decreased compared to PTZ control (repeated measures ANOVA) are marked *, **, and *** (p<0.05, p<0.01, and p<0.001, respectively); standard errors are shown. F values (treatment group-dependent variability): (A) 55.88, (B) 77.26, (C) 144.3, (D) 107.6, (E) 124.7, (F) 65.73, (G) 80.58, (H) 79.56, (I) 70.39, (J) 153.2, (K) 70.29, (L) 80.36, (M) 97.76, (N) 68.3, (O) 137.8. Total number of larvae used are indicated in brackets.