<p>Mice in all groups were treated as the same with the front method. The animals were sacrificed 24 h after the last CCl<sub>4</sub> administration and the liver was removed, fixed and embedded in paraffin. Sections were stained with Masson (200×). (A) Liver tissue of a control mouse. (B) Liver tissue of a mouse treated with CCl<sub>4</sub>, presenting severe liver fibrosis (arrow 1) and ballooning degeneration (arrow 2) aroud the portal vein. (C) Liver tissue of a mouse treated with silymarin (100 mg/kg, i.g.), presenting well-developed septa, showing moderate liver fibrosis (arrow 1) and hepatocyte necrosis with inflammatory cell (arrow 2) infiltration around the portal vein. (D) Liver tissue of a mouse treated with GA (25 mg/kg, i.g.), ...
<p>Liver fibrosis was induced by intraperitoneal injection of CCl<sub><b>4</b></sub> and different d...
This study examined the possible hepatoprotective effect of aminoguanidine in comparison with silyma...
<p>The pathological findings of c-lipo- or PBS-pretreated mice 48 h after CCl<sub>4</sub> challenge....
<p>Mice in all groups were treated as the same with the front method. The animals were sacrificed 24...
<p>Mice in all groups were treated as the same with the front method. The animals were sacrificed 24...
<p>The mice were treated with GA, silymarin or vehicle every day for 4 weeks on the other day of the...
<p>The mice were treated with GA, silymarin or vehicle every day for 4 weeks on the other day of the...
<p>Mice in all groups were treated as the same with the front method. Liver fibrosis was determined ...
<p>Mice in all groups were treated as the same with the front method. The animals were sacrificed 24...
<p>Total RNA was extracted from mice liver tissues of GA-treated, CCl<sub>4</sub>-administrated, sil...
<p>Male C57BL/6J WT mice (n = 4) and IDO-KO mice (n = 5) were treated with CCl<sub>4</sub> (1 mL/kg,...
<p>Potential mechanisms for anti-fibrosis mechanism of GA against CCl<sub>4</sub>-induced liver fibr...
<p>Liver fibrosis was induced by intraperitoneal injection of CCl<sub>4</sub> twice a week for 3 wee...
<p>(<b>A</b>) Schematic illustration for <i>in vivo</i> experiments. Each group except the control r...
<p>Mice were CCl<sub>4</sub> treated twice a week for a total period of 4 weeks. After the second we...
<p>Liver fibrosis was induced by intraperitoneal injection of CCl<sub><b>4</b></sub> and different d...
This study examined the possible hepatoprotective effect of aminoguanidine in comparison with silyma...
<p>The pathological findings of c-lipo- or PBS-pretreated mice 48 h after CCl<sub>4</sub> challenge....
<p>Mice in all groups were treated as the same with the front method. The animals were sacrificed 24...
<p>Mice in all groups were treated as the same with the front method. The animals were sacrificed 24...
<p>The mice were treated with GA, silymarin or vehicle every day for 4 weeks on the other day of the...
<p>The mice were treated with GA, silymarin or vehicle every day for 4 weeks on the other day of the...
<p>Mice in all groups were treated as the same with the front method. Liver fibrosis was determined ...
<p>Mice in all groups were treated as the same with the front method. The animals were sacrificed 24...
<p>Total RNA was extracted from mice liver tissues of GA-treated, CCl<sub>4</sub>-administrated, sil...
<p>Male C57BL/6J WT mice (n = 4) and IDO-KO mice (n = 5) were treated with CCl<sub>4</sub> (1 mL/kg,...
<p>Potential mechanisms for anti-fibrosis mechanism of GA against CCl<sub>4</sub>-induced liver fibr...
<p>Liver fibrosis was induced by intraperitoneal injection of CCl<sub>4</sub> twice a week for 3 wee...
<p>(<b>A</b>) Schematic illustration for <i>in vivo</i> experiments. Each group except the control r...
<p>Mice were CCl<sub>4</sub> treated twice a week for a total period of 4 weeks. After the second we...
<p>Liver fibrosis was induced by intraperitoneal injection of CCl<sub><b>4</b></sub> and different d...
This study examined the possible hepatoprotective effect of aminoguanidine in comparison with silyma...
<p>The pathological findings of c-lipo- or PBS-pretreated mice 48 h after CCl<sub>4</sub> challenge....