A_2AAR upregulation in RA patients and <i>in vitro</i> stimulation by CGS 21680 increased IL-10 production.

<p>(A) A_2AAR Bmax values in lymphocytes from RA patients evaluated at different time points of treatment with MTX, anti-TNFα drugs or RTX. Data are expressed as mean ± SD. *, <i>p<</i>0.01 vs healthy controls (white bar, Bmax = 57±46 fmol/mg protein); #, <i>p</i><0.01 vs t = 0. (B) Effect of CGS 21680 (1 nM–10 µM) and SCH 58261 (1 µM) on IL-10 production in cultured lymphocytes from untreated RA patients. Data are expressed as mean ± SD. *, <i>p</i><0.05vs basal; **, <i>p</i><0.01 vs basal; #, <i>p</i><0.01 vs CGS 21680 (1 µM).