Antioxidative effects of the treatment with GA on the CCl₄-induced liver fibrosis.

<p>The mice were treated with GA, silymarin or vehicle every day for 4 weeks on the other day of the first double-dosage administration with CCl_4. Then every 6 days during this month, CCl₄ dissolved in corn oil (6.4 g/kg of body weight, s.c.) was administrated under the skin between head and neck to each group, except Cont. The activities of antioxidant enzyme in the liver were determined. Cont, normal control; CCl₄, CCl₄ alone; Sil, CCl₄+100 mg/kg silymarin; GA25, CCl₄+25 mg/kg GA; GA50, CCl₄+50 mg/kg GA; GA100, CCl₄+100 mg/kg GA. Data are presented as the mean± SD (n = 8) in each group.</p>a<p>Significantly different from the control at <i>p</i><0.05.</p>b<p>Significantly different from the CCl₄ at <i>p</i><0.05.