The effect of p.o. administration of H₂ on diabetes in STZ-induced type 1 diabetic mice.

<p>(A) Blood glucose in the high content hydrogen water (HHW) and natural hydrogen water (NHW) groups at every weekly measurement showed a tendency to decrease compared to control, but, these decreases were not statistically significant (n = 6 for each group). (B, C) The AUC values of NHW group in the day-90 and day-120 IPGTTs were significantly decreased. Although the AUC values of the LHW, HHW groups in the day-90 and day-120 IPGTTs showed a tendency to decrease, these decrease were not statistically significant (n = 6 for each group). (D) As described in the Results, several mice were lost due to dehydration, so we combined the data of two groups [HHW (n = 2) and LHW (n = 2)] together. Glycated albumin in the combined LHW and HHW group (n = 4) and NHW group (n = 6) was significantly lower than the control group (n = 6). Comparisons with controls were performed by Dunnett’s multipule comparison test. *<i>P</i><0.05, **<i>P</i><0.01.