Spatial and contextual fear memory, anxiety, sleep-wake cycles and motor performance of lesioned mice are normal.

<p>(A) Mean (± SEM) percent context-elicited freezing 24 hours after fear conditioning training (5 random 0.8 mV foot-shocks). No difference in percent freezing during test was detected in lesioned mice compared to control mice that received foot-shocks,. (B) Mean (± SEM) time spent in the novel arm in the Y-maze. Lesioned mice spent an equivalent amount of time exploring the novel arm of the Y-maze to control mice. (C) Mean (± SEM) time achieved in the accelerating Rota-rod test. All mice successfully completed the 3 minute test with no falls recorded. (D) Mean (± SEM) initial time to enter, total time, and number of entries to the light area in the light/dark test of anxiety. No difference was detected between lesioned and control mice in the initial time taken to enter the light area or in the total time spent in the this area. However, lesioned mice made more entries into the light area during the 5 minute test than control mice (mu-p75-SAP vs Rb-IgG-SAP, *p<0.05). (E) Mean (± SEM) locomotor activity in 1 hour time bins over 36 hours incorporating 2 wake and 1 sleep cycles. No difference in locomotor activity was found between lesioned and control mice in either the wake or sleep cycle.