Effects of SPX on the infiltration of M1 and M2 macrophages and on inflammatory responses in the pancreas.

<p>(<b>A and B</b>) Representative images of CD11c staining (left) and CD206 staining (right) in intra-islet areas (<b>A</b>) and intra-lobular areas (<b>B</b>) in pancreas sections from each group. (<b>C−E</b>) Percentage of CD11c-positive area (<b>C</b>) and CD206-positive area (<b>D</b>) and M1/M2 ratio (<b>E</b>) in intra-islet areas. (<b>F−H</b>) Percentage of CD11c-positive area (<b>F</b>) and CD206-positive area (<b>G</b>) and M1/M2 ratio (<b>H</b>) in intra-lobular areas. (<b>J and K</b>) Content of pro- and anti-inflammatory cytokines (<b>J</b>) and interleukin (IL)-10/IL-1β ratio (<b>K</b>) in the pancreas in each group (<i>n</i> = 6). *<i>P</i><0.05 vs. the Standard-Sham group. Scale bar = 100 µm. Treatment groups: Standard-Sham, fed standard chow and sham-operated; Standard-SPX, fed standard chow and splenectomized.