mAb 232-1F does not block RSV G protein induced leukocyte migration or RSV-associated pulmonary inflammation.

<p>(A) mAb 232-1F was examined for its ability to block RSV G protein induced leukocyte migration in vitro compared to mAb 232-1F and mAb 131-2G. An anti-RSV F antibody (nIg) was used a negative control. Data is expressed as percent inhibition of leukocyte chemotaxis. (B) BAL cells from antibody-treated (300 µg/mouse, nIg, mAb 232-1F and mAb 131-2G) mice were harvested on days 3, 5 and day 7 post-RSV infection. The data are expressed as the mean number of BAL cells (±SE) per ml. (C) IFN-γ cytokine production (pg/mL ±SE) in cell-free BAL fluid were determined and the virus titers were determined by immunostaining plaque assay (PFU/g of tissue; ±SE) (D). Asterisks represents statistical significance (p<0.05) as determined by comparing nIg treated and mAb treated group. Representative results from two separate experiments are shown. ND indicates virus titers below the level of detection.