Melatonin attenuates APAP-induced acute liver injury.

<p>Mice were treated as Materials and Methods. Liver samples were collected at 4 h after APAP administration. Representative photomicrographs of liver histology from mice treated with saline (A as control), APAP alone (B), melatonin alone (C), and combination of APAP and melatonin (D) are shown (H & E, magnification: 100×). (E) Sera were collected at 4 h after APAP administration. Serum ALT was measured. All data were expressed as means ± SEM (n = 6). **<i>P</i><0.01 as compared with the control. ‡‡ <i>P</i><0.01 as compared with APAP group.