<p>Parameters were measured after 4weeks of treatment with carbenoxolone or vehicle (50 mg/kg body weight/day). Values are means ± SEM for 6 animals for group. #<i>p</i><0.05, ##<i>p</i><0.01 and ### <i>p</i><0.001 comparing vehicle-treated lean and obese rats at the respective time point. *<i>p</i><0.05, **<i>p</i><0.01 and *** <i>p</i><0.001 comparing carbenoxolone-treated animals with vehicle-treated animals of the same phenotype at the respective time point.</p
<p>Animals (n = 8 per group) received a single injection of vehicle, lurasidone (0.2, 0.8 or 2.0 mg/...
(A) An OGTT was performed before the 6 weeks of administration, and area under the curve (AUC) is sh...
<p>Animals at the end of the 7-week treatments were fasted overnight for glucose tolerance tests, or...
<p>(A). Fed-state corticosterone. (B). Fasting corticosterone. (C). Fed-state triglycerides. (D). Fa...
<p>Values represent means ± SEM of 6 rats per group. LC, Lean control; OC, Obese control; LT, Lean- ...
<p>(A). fat percentage. (B). Lean body mass. (C). Fat free mass. Body composition was measured by TO...
<p>(A). Hepatic triglyceride content. (B). Hepatic glycogen content. (C). Photographs of liver tissu...
<p>(A). Liver. (B). Subcutaneous adipose tissue. (C). Omental adipose tissue. (D). Skeletal muscle. ...
<p>(A). Stearoyl CoA desaturase 1 (SCD1). (B). Malic enzyme 1 (ME1). (C). Macrophage expressed gene ...
Increased activity of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD-1) has been implicate...
BACKGROUND: 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regulates local glucocorticoid act...
11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regulates local glucocorticoid action in tissu...
<p>Within each OGTT, plasma glucose levels are measured at baseline (0) and 15, 30, 60 and 120 min a...
<p>Data represent mean ± SD (n = 10 per group). **<i>P</i><0.01 versus the control group; <sup>#</su...
<p>ZDF rats were treated with different doses of canagliflozin or vehicle for 4 weeks. Fed plasma gl...
<p>Animals (n = 8 per group) received a single injection of vehicle, lurasidone (0.2, 0.8 or 2.0 mg/...
(A) An OGTT was performed before the 6 weeks of administration, and area under the curve (AUC) is sh...
<p>Animals at the end of the 7-week treatments were fasted overnight for glucose tolerance tests, or...
<p>(A). Fed-state corticosterone. (B). Fasting corticosterone. (C). Fed-state triglycerides. (D). Fa...
<p>Values represent means ± SEM of 6 rats per group. LC, Lean control; OC, Obese control; LT, Lean- ...
<p>(A). fat percentage. (B). Lean body mass. (C). Fat free mass. Body composition was measured by TO...
<p>(A). Hepatic triglyceride content. (B). Hepatic glycogen content. (C). Photographs of liver tissu...
<p>(A). Liver. (B). Subcutaneous adipose tissue. (C). Omental adipose tissue. (D). Skeletal muscle. ...
<p>(A). Stearoyl CoA desaturase 1 (SCD1). (B). Malic enzyme 1 (ME1). (C). Macrophage expressed gene ...
Increased activity of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD-1) has been implicate...
BACKGROUND: 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regulates local glucocorticoid act...
11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regulates local glucocorticoid action in tissu...
<p>Within each OGTT, plasma glucose levels are measured at baseline (0) and 15, 30, 60 and 120 min a...
<p>Data represent mean ± SD (n = 10 per group). **<i>P</i><0.01 versus the control group; <sup>#</su...
<p>ZDF rats were treated with different doses of canagliflozin or vehicle for 4 weeks. Fed plasma gl...
<p>Animals (n = 8 per group) received a single injection of vehicle, lurasidone (0.2, 0.8 or 2.0 mg/...
(A) An OGTT was performed before the 6 weeks of administration, and area under the curve (AUC) is sh...
<p>Animals at the end of the 7-week treatments were fasted overnight for glucose tolerance tests, or...