Exposure to FGN induces inflammation in the colon of mice with eosinophilia.

<p>Mice were induced the eosinophilia in the intestine by parasitic infections. Naïve mice (A1) did not have any specific treatment. A2–A3, naïve mice were treated with saline (A2) or FGN (A3) via the intrarectal route. A4–A7, mice with eosinophilia were exposed to FGN via intrarectal route and depletion of DCs (A5), or anti-CD98 antibody (A6), or anti-Gal-3 antibody (A7). A8, mice with intestinal eosinophilia were treated with 50% ethanol via the intrarectal route. Image magnification: ×200. B, the bars indicate the body weight records; the data were presented as a percentage of the original body weight. C, the bars indicate the MPO level in colon tissue extracts. D, the bars indicate the frequency of Eo in the colon mucosa (the counts were averaged from 20 fields per mouse). The data in B-D were expressed as mean ± SEM. *, p<0.05, compared with group A1. Each group had 6 mice.