TAK1^ΔM mice develop splenomegaly and have shortened lifespans.

<p>(<b>A–B</b>) Decreased body weights of aged TAK1^ΔM mice. The mean (± SEM) body weights of cohorts of female (<b>A</b>) and male (<b>B</b>) TAK1^F/+ and TAK1^ΔM mice age 4–24 weeks at 4-week intervals are shown. For TAK1^F/+ females, n = 16–36; for males, n = 16–22. For TAK1^ΔM females, n = 16–31; for males, n = 9–19. For females: <i>P</i><0.0001 (4 weeks), <i>P</i> = 0.0071 (8 weeks), <i>P</i> = 0.0206 (12 weeks), <i>P</i> = 0.0003 (16 weeks), <i>P</i> = 0.0020 (20 weeks), and <i>P</i> = 0.0006 (24 weeks). For males: <i>P</i> = 0.0005 (4 weeks), <i>P</i> = 0.0637 (8 weeks), <i>P</i> = 0.0169 (12 weeks), P = 0.0004 (16 weeks), <i>P</i> = 0.0017 (20 weeks), and <i>P</i> = 0.0013 (24 weeks). (<b>C</b>) TAK1^ΔM mice developed splenomegaly. Mice (age 5–20 weeks) were euthanized, and their body weights were measured. The spleens, hearts, and kidneys were harvested and weighed; values are the mean ± SEM. Spleen, TAK1^F/+ n = 41 and TAK1^ΔM n = 53; heart, TAK1^F/+ n = 32 and TAK1^ΔM n = 35; Kidneys, TAK1^F/+ n = 19 and TAK1^ΔM n = 27. *<i>P</i><0.0001; **<i>P</i><0.05. A representative image of spleens from TAK1^F/+ and TAK1^ΔM mice (<i>inset</i>). (<b>D</b>) Kaplan-Meier analysis of a cohort of TAK1^F/+ (n = 23) and TAK1^ΔM (n = 21) mice showing spontaneous death of TAK1^ΔM mice age 16–43 weeks, with a median survival duration of 29 weeks (<i>P</i><0.0001). (<b>E</b>) Spleen weights of diseased TAK1^ΔM mice (n = 29) and control TAK1^F/+ mice (n = 8).