Signaling pathways activated in JSRV Env-induced lung tumors.

<p>The JSRV Env protein leads to activation of signals through both the PI3K/Akt and MAPK pathways leading to cell cycle progression, regulation of protein translation and evasion of apoptosis. Kinases are represented by squares, phosphatases by diamonds, and transcription factors by circles. Possible interactions, or other unidentified factors presumed to be involved in the transformation by JSRV Env are indicated with questions marks (?) or by a red colored box, as in the case of PI3K. Signaling molecules activated exclusively in the NOD/SCID mouse model are depicted in white. Signaling molecules uniquely activated in the C57BL/6 mouse model and RJenvC1 tumor cell line are depicted in black. Signaling molecules activated in all three models are depicted in grey. An asterisk on PTEN indicates that gene expression reduced in the RJenvC1 tumor cell line. Note that in the absence of functional assays, such as those involving inhibitors, the arrows and inhibition bars are only speculative for the tumors reported here.