Complete protection against vaginal SHIV transmission by intermittent PrEP with Truvada.

<p>Survival curves represent the cumulative percentage of uninfected macaques as a function of the number of months in the study period (4 challenges per month). Control macaques become infected after a median of 3.5 exposures or about 1 menstrual cycle. Virus challenges in the macaques receiving Truvada were stopped after 18 SHIV_SF162P3 exposures or about 4.5 menstrual cycles. Protected animals remained seronegative and RNA/DNA negative during a follow up period of 18 weeks.