Benzene toxicity in human hematopoietic stem/progenitor cells from Hu-NOG mice.

<p>(A) Dot plot of a bone marrow sample from untreated Hu-NOG mice stained with hCD38 and hCD34 within the Lin⁻ gate. (B) Numbers of Lin⁻hCD38⁻hCD34⁺ cells in the bone marrow of Hu-NOG mice after benzene administration (n = 7 or n = 8). (C) Numbers of colony-forming unit-granulocyte/erythroid/macrophage/megakaryocytes (CFU-GEMMs) arising from the bone marrow cells of Hu-NOG mice after benzene administration (n = 6–8). Each point represents the mean ± SD of each group. * <i>p</i><0.05 and ** <i>p</i><0.01 represent significant differences compared with untreated mice, as determined by <i>t</i> tests.