Notch3 in normal pancreas and PDAC.

<p>a) Notch3 in the cytoplasm of normal pancreatic ductal epithelial cells; b) resected PDAC demonstrating strong cytoplasmic Notch3 with some positive nuclei; c) resected PDAC demonstrating largely nuclear stain; d) nuclear stain in an area of perineural invasion; e) strong cytoplasmic and nuclear stain in an unresectable specimen; f) Notch3 in a metastatic deposit in a local lymph node. (Original magnification a – 40x, b-f – 20x).