Mangafodipir limits the enzyme leakage and improve liver function.

<p>(A) Alanine amino transferase (ALT), Aspartate amino transferase (AST) and Lactate dehydrogenase (LDH) levels were measured in liver perfusates at the end of normothermic reperfusion (T = 120 min). (B) Bile production was assessed in livers along the 120 min of normothermic reperfusion. Biliary Bilirubin excretion (C) perfusate Albumin (D) and alkaline phosphatase (E) levels were determined at the end of normothermic reperfusion. Control group: untreated rat livers immediately submitted to 120 min of normothermic reperfusion; I/R group: liver procured from vehicle (NaCl) pretreated rats, cold stored for 24 h at 4°C and submitted to 120 min of normothermic reperfusion; MnDPDP+I/R group: livers procured from 3, 5 or 15 µmol/kg MnDPDP-pretreated rats, cold stored for 24 h at 4°C and submitted to 120 min of normothermic reperfusion. Results were expressed in UI/L. * <i>p</i><0.05: either I/R or MnDPDP+I/R versus Control; ⁺<i>p</i><0.05: MnDPDP+I/R versus I/R. £ <i>p</i><0.05: MnDPDP+I/R 15 µmol/kg versus 5 µmol/kg.