Effect of NPB112 on hepatic and peripheral insulin sensitivity in DIO mice.

<p>A. Fasting glucose levels in the hyperinsulinemic-euglycemic clamp studies before insulin infusion for mice treated with vehicle or NPB112 at 5.0 mg/kg. <i>n = 5</i> per group. B. Hepatic insulin action as the percent suppression of basal hepatic glucose production before insulin infusion for mice treated with vehicle or NPB112 at 5.0 mg/kg. <i>n = 5</i> per group. C. Hepatic insulin action as the percent suppression of clamp hepatic glucose production after insulin infusion at the rate of 15∼18 pmol/kg/min for mice treated with vehicle or NPB112 at 5.0 mg/kg. The clamp conditions were same as in A. <i>n = 5</i> per group. D. Steady-state whole-body glucose infusion rate (GIR) during the last 30 min of the hyperinsulinemic-euglycemic clamp studies in mice treated with vehicle or NPB112 at 5.0 mg/kg. <i>n = 5</i> per group. *, p<0.01 compared to control mice with vehicle.