Univariate and multivariate time dependent cox regression analyses for patient death and renal death.

<p>Multivariate time-dependent cox regression analysis for patient-death was included age, sex, clinical manifestations of edema/gross hematuria, co-morbidities of hypertension/cancer, BMI, GFR, anemia, albumin <3.5g/dL, SBP ≥140 mmHg, DBP ≥90 mmHg, proteinuria ≥1 g/day, and pathologic change of global sclerosis, presence of crescent, interstitial inflammation and tubular atrophy/interstitial fibrosis. Sex and global sclerosis did not meet proportional hazards assumption for Cox model. Global sclerosis interacted with GFR and interstitial inflammatory cell infiltration. BMI interacted with age. Therefore such interactions were considered in this model.</p><p>Multivariate time-dependent cox regression analysis for renal-death was included age, sex, clinical manifestations of edema/gross hematuria, co-morbidities of diabetes/hypertension/cancer, GFR, anemia, albumin <3.5g/dL, SBP ≥140 mmHg, DBP ≥90 mmHg, proteinuria ≥1 g/day, pathologic change of segmental sclerosis, and treatment history with statin and renin-angiotensin system blockades. Sex and age were considered changes of proportional hazard according to time progression. Global sclerosis and other tubulointerstial changes were excluded in the final model because of severe interaction with GFR.</p><p>Abbreviations: SBP, systolic blood pressure; ESRD, end-stage renal disease; eGFR, estimated glomerular filtration rate; HR, Hazard ratio; CI, confidence interval.