Nicotine CPP is attenuated in CaMKIV −/− mice.

<p>Male CaMKIV +/+ and +/− mice develop a significant preference for nicotine (0.5 mg/kg, s.c.); however, this effect is eliminated in CaMKIV −/− mice. *denotes p<0.05 vs. corresponding saline groups and CaMKIV −/− nicotine group. **denotes p<0.05 vs. corresponding saline groups. Each point represents the mean ± SEM for 8–15 mice per group. The y-axis represents the preference score (drug-paired side test day – drug paired side baseline) in seconds. The x-axis represents the treatment.