The nucleoside backbone does not influence plasma mtDNA.

<p>Mitochondrial DNA levels were measured in plasma (left) and 3000 g supernatant (right) from either untreated individuals (None) or subjects taking the indicated nucleoside analogues at the time of phlebotomy (x-axis). Boxplots (median level, 25% and 75% quartiles, and 1.5 * interquartile range) show the mtDNA level (copy number, y-axis) for each fraction. P values are reported in the text.