Concentration-dependent contraction to noradrenaline in endothelium-intact (E+) and denuded (E−) mesenteric resistance arteries from 3- (A), 6- (B) and 12-month-old offspring of diabetic (O-DR) and non-diabetic rats (O-CR).

<p>Results (mean±S.E.M.) were expressed as a percentage of the initial contraction elicited by KCl. N = 6−7 animals each curve.