Multiple sequence alignment of <i>bc</i>PadR1, <i>bc</i>PadR2, and other members of the PadR-s2 subfamily.

<p>Only sequences for which structures are available in the PDB are shown in the alignment. The PadR-s2 proteins with unpublished structures are addressed by their PDB entry names: 1XMA, a putative transcriptional regulator from <i>Clostridium thermocellum</i>; 3HHH, a putative transcriptional regulator from <i>Enterococcus faecalis</i> V583; 3L7W, uncharacterized protein SMU.1704 from <i>Streptococcus mutans</i> UA159; 3RI2, a putative transcriptional regulator from <i>Eggerthella lenta</i> DSM 2243. Residues that participate in dimerization (for <i>bc</i>PadR1, <i>bc</i>PadR2, and LmrR) and/or have a role in drug binding (only for LmrR) are indicated by small spheres below the sequences. The consensus sequence is derived from a multiple sequence alignment of 2156 PadR-s2 proteins using as criteria that the conserved residue(s) should be present in at least 50% of the sequences.