Mfsd2a KO mice develop glucose intolerance but are resistant to diet-induced obesity.

<p><i>A,</i> Growth curves for WT and KO male mice fed chow or high-fat diet (HFD) starting at 6 weeks of age (n = 4–8 per genotype). <i>B and C</i>, Average body weight (left), absolute adiposity (center), and relative adiposity (right) for WT (open bar) and KO (closed bar) cohorts fed <i>B,</i> 10 days and <i>C,</i> 10 weeks of HFD. <i>D,</i> WT and <i>E,</i> KO livers stained with ORO for neutral lipid following 10 weeks of HFD. <i>F,</i> GTT after overnight fast of WT and KO males fed HFD for 10 weeks (n = 3–4 mice per genotype, data representative of two independent experiments). Data are displayed as mean ± SEM. * p<0.05, ** p<0.01, *** p<0.001, N.S. = not significant.