Histopathology of pulmonary lesions of anti-CD25-treated and untreated A/J and B10.A mice at week 10 post-infection with 1×10⁶<i>P. brasiliensis</i> yeasts.

<p>IgG-treated (A, B) and anti-CD25-treated (C, D) A/J mice showed equivalent diffuse inflammatory reactions characterized by a small number of yeasts in the presence of elevated number of macrophages, lymphocytes and plasma cells; small portions of lung tissue were preserved, with limited signs of inflammatory cell recruitment. IgG-treated B10.A mice (E, F) presented an elevated number of well-defined, confluent, necrotic, granulomas of various sizes (E) containing an elevated number of fungal cells (arrows in F); these lesions occupy a large area of lung tissue (E, F). Compared with control B10.A mice, anti-CD25-treated B10.A mice showed significantly smaller lesions (G) containing a few number of yeasts (H). A, C, E, G, (HE, X 100); B, D, F, H (Groccot X 100). I- Total area of lung lesions of mice (n = 6) at week 10 after infection. ** (<i>P</i><0.01), and *** (<i>P</i><0.001) compared with IgG-treated controls or the susceptible strain.