Visual behaviour in ST and EE mice.

<p>(A) Visual acuity of rd10 mice is significantly higher in EE than in ST at all ages tested. Two-way ANOVA test with Bonferroni post-hoc analysis, ***p<0.001. Each column shows the mean (and SEM) response for a group of 10 animals tested with a Prusky water maze. The valued shown for the wild type strain (dotted line) is the one reported in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050726#pone.0050726-Cancedda1" target="_blank">[21]</a>. (B) Visual acuity of EE (upper panel) and ST mice (bottom panel) as a function of time. Two way Anova test and Bonferroni correction show that visual acuity decays more rapidly in ST than in EE mice. (C) At P45, contrast sensitivity, assessed as the minimum contrast detected, is already poor in rd10 mice raised in ST, and becomes worse with age. rd10 mice raised in EE have better contrast sensitivity than ST counterparts, although showing an age-related decline. Two-way ANOVA test with Bonferroni post-hoc analysis, ***p<0.001. The value shown for the wild type strain (dotted line) is the one reported in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050726#pone.0050726-Histed1" target="_blank">[37]</a>. (D) Again, two-way Anova matched and Bonferroni correction highlight the age dependent decline in contrast sensitivity. ***p<0.001; **p<0.01; *p<0.05.