ERK5 icKO mice are impaired in remote memory when the <i>erk5</i> gene was inducibly deleted prior to training.

<p>A) Schematic depiction of the experimental design. Mice were treated with tamoxifen to delete <i>erk5</i> before contextual fear conditioning with the 1×0.7 mA foot shock paradigm. B) Freezing behavior in the shocking context 1 d after training does not differ between ERK5 icKO and control mice. C) Remote contextual memory is impaired in ERK5 icKO mice when tested 5 wks post-training. D) Minimal freezing behavior is observed in a novel context at both 1 d and 5 wks post-training for all treatment groups. E) Amygdala-dependent, cued-fear conditioning is normal in ERK5 icKO mice at both 1 d and 5 wks post training.