Comparison of the structures of human β subunits in free and NADP⁺ bound states.

<p>The figure depicts the structure of free β subunits (white; 2YDY) and that of the NADP⁺ bound state (red; 2YDX). Cofactor and resveratrol molecules are shown as sticks with coloured carbon (black), nitrogen (red), phosphorus (orange) and oxygen (blue) atoms. Three regions not visible in the apoenzyme and ordered upon NADP⁺ binding are highlighted: F60-A77 (A), A95-N113 (B), and D325-F333 (C); only A and B regions are linked to NADP⁺. On the right the surface of the β dimer is shown as found in the NADP⁺ bound crystal structure, illustrating location of A and C regions in the dimer interface.