The NADP⁺ binding site in the β subunit.

<p>The figure shows the structure of the NADP⁺ site with the protein residues shown as wheat sticks. Colour codes are as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050329#pone-0050329-g004" target="_blank">Figure 4</a>. Panel A depicts recognition of the phosphate moieties, showing that segment A is involved in NADP⁺/NAD⁺ discrimination by linking the additional phosphate group. This phosphate is linked to R62 (region A) which establishes a strong network of atomic interactions that connects to R97 (region B), conforming the NADP⁺ binding site. Panel B shows a detail of the residues that bind NADP⁺ and have been mutated in this work.