<p>Genotypes are indicated at left, where 1 Rho is mRho<sup>+/−</sup>, 2 Rho is mRho<sup>+/+</sup>, and 3 Rho is mRho<sup>+/+</sup>NHRE<sup>+/0</sup>. Ages in months are indicated at the top. Retinal layers are abbreviated at right, where ROS is rod outer segment, RIS is rod inner segment, ONL is outer nuclear layer, OPL is outer plexiform layer, INL is inner nuclear layer, and IPL is inner plexiform layer.</p
<p>OS/IS/ELM, outer segment/inner segment/external limiting membrane; ONL, outer nuclear layer; OPL,...
<p>(A to D) Vertical retinal sections from 45 (A, B) and 60-day-old (C, D) rd10 mice raised in stand...
<p>The outbreeding of Pde6b<sup>rd1</sup> mutation successfully restores the WT histological phenoty...
<p>Genotypes are indicated at left, where 1Rho+P23H is mRho<sup>+/−</sup>P23H<sup>+/0</sup>, 2 Rho+P...
<p>A. Light micrographs of Epon resin embedded retinal sections of 4-wk-old littermates. The organiz...
<p>(A, B, E & F) Representative images of Hematoxylin and eosin (H&E) stained 6 μ cross sections of ...
<p><b>A,</b> Normal retinal layers in a healthy eye assessed by cross-sectional OCT in comparison wi...
<p>(A) Fundus photographs at P21 indicate atypical RPE characteristic of the grainy retinal appearan...
<p>Light microscopic images of semi-thin sections of retinas from wild-type (wt/wt) and homozygous <...
<p><b>A</b>) Photographs of plastic retina sections from Rd9/Y and B6 mice at the ages indicated. Mo...
<p>A. Rhodopsin mRNA in wild type mice (mRho+/+), hRho-GFP homozygous mice (hRhoG/hRhoG), ID2-hRho-G...
<p>(A) Retinas from age-matched hRho-GFP and P23H-hRho-GFP mice were sectioned and stained with DAPI...
<p>H&E stained cross-sections show that the RPE membrane (arrows) is broken and the retina is thicke...
<p>(A) Northern blot analysis of rhodopsin mRNA from various mouse lines. Copy numbers of wild type ...
<p>The mean outer nuclear layer (ONL) of the retinas of R6/2 and wild-type (WT) mice are virtually i...
<p>OS/IS/ELM, outer segment/inner segment/external limiting membrane; ONL, outer nuclear layer; OPL,...
<p>(A to D) Vertical retinal sections from 45 (A, B) and 60-day-old (C, D) rd10 mice raised in stand...
<p>The outbreeding of Pde6b<sup>rd1</sup> mutation successfully restores the WT histological phenoty...
<p>Genotypes are indicated at left, where 1Rho+P23H is mRho<sup>+/−</sup>P23H<sup>+/0</sup>, 2 Rho+P...
<p>A. Light micrographs of Epon resin embedded retinal sections of 4-wk-old littermates. The organiz...
<p>(A, B, E & F) Representative images of Hematoxylin and eosin (H&E) stained 6 μ cross sections of ...
<p><b>A,</b> Normal retinal layers in a healthy eye assessed by cross-sectional OCT in comparison wi...
<p>(A) Fundus photographs at P21 indicate atypical RPE characteristic of the grainy retinal appearan...
<p>Light microscopic images of semi-thin sections of retinas from wild-type (wt/wt) and homozygous <...
<p><b>A</b>) Photographs of plastic retina sections from Rd9/Y and B6 mice at the ages indicated. Mo...
<p>A. Rhodopsin mRNA in wild type mice (mRho+/+), hRho-GFP homozygous mice (hRhoG/hRhoG), ID2-hRho-G...
<p>(A) Retinas from age-matched hRho-GFP and P23H-hRho-GFP mice were sectioned and stained with DAPI...
<p>H&E stained cross-sections show that the RPE membrane (arrows) is broken and the retina is thicke...
<p>(A) Northern blot analysis of rhodopsin mRNA from various mouse lines. Copy numbers of wild type ...
<p>The mean outer nuclear layer (ONL) of the retinas of R6/2 and wild-type (WT) mice are virtually i...
<p>OS/IS/ELM, outer segment/inner segment/external limiting membrane; ONL, outer nuclear layer; OPL,...
<p>(A to D) Vertical retinal sections from 45 (A, B) and 60-day-old (C, D) rd10 mice raised in stand...
<p>The outbreeding of Pde6b<sup>rd1</sup> mutation successfully restores the WT histological phenoty...