Association between <i>SLC6A2</i> SNPs and treatment response in the MSDP group.

<p>CGI = Clinical Global Impression, PBO = placebo, Conners’ P = Conners’ Parents, Conners’ T = Conners’ Teachers, RI = Restless-Impulsive, EL = Emotional Lability, RASS = Restricted Academic Situation Scale.</p><p>Three major haplotype blocks in <i>SLC6A2</i> are depicted above: Block 1 (rs1362621, rs2397771, rs168924, rs2242446, rs3785143, rs192303, rs41154); Block 2 (rs36017, rs10521329, rs3785155, rs5564, rs11568324, rs2279805, rs8047672, rs5569, rs998424, rs36009); and Block 3 (rs1800887, rs2242447, rs15534).</p><p>Significance (p) value ranges are depicted as follows: For OVER-TRANSMISSION of alleles = <b>+4</b> (≤0.00001), <b>+3</b> (0.0001–0.0009), <b>+2</b> (0.001–0.009), and <b>+1</b> (0.01–0.049).</p><p>For UNDER-TRANSMISSION of alleles = −<b>4</b> (≤0.00001), −<b>3</b> (0.0001–0.0009), −<b>2</b> (0.001–0.009) and −<b>1</b> (0.01–0.049).