The combination of pan Bcl-2 inhibitor AT-101 with aATC immunotherapy inhibits Stat3 phosphorylation.

<p>L3.6pl cells that were either pretreated with AT-101 for 24 h or left untreated followed by additional incubation with ATC or aATC for 4 h. Proportion of Stat3 positive cells and MFI were gated on tumor cells. Top panel show histogram overlays representing isotype control and phosphor-Stat3 positive tumor cells. Bottom panel shows the graphic representation of MFI under the indicated experimental conditions.