Visual phenotype of the <i>Fatp1</i>^−/− mouse.

<p>A. Histology of the retina. Ch: choroid. RPE: retinal pigment epithelium. POS: PR outer segments. PIS: PR inner segments. ONL: outer nuclear layer. OPL: outer plexiform layer. INL: inner nuclear layer. IPL: inner plexiform layer. GCL: ganglion cell layer. WT: <i>Fatp1</i>^+/+. KO: <i>Fatp1^−/−</i>. B. TEM of WT and KO retinas. BM: Bruch membrane. C. Electroretinography of <i>Fatp1</i>^+/+ (<i>n</i> = 29) and <i>Fatp1^−/−</i> (<i>n</i> = 23) mice. * <i>p</i><0.05; ** <i>p</i><0.01; *** <i>p</i><0.001. The statistical analyses were performed initially for the whole curve (line above the graph) and subsequently for each point. D. b-wave on a-wave ratio of the ERG experiments. Error bars represent SEM. E. Quantification of the retinal coupled-rhodopsin (<i>n</i> = 4 <i>Fatp1</i>^+/+ and <i>n</i> = 4 <i>Fatp1^−/−</i>) in mice aged 5 to 8 months. Error bars represent SEM. The retinal histology is unchanged in the <i>Fatp1^−/−</i> mice. <i>Fatp1^−/−</i> PRs present a lower response to light flashes and this decrease is not due to a decrease in the level of retinal coupled-rhodopsin in these animals.