In vivo survival of WT and Δ<i>pmrF S</i>. Typhimurium in C57BL/6 and MMP7 KO mice.

<p>C57BL/6 (WT) and background-matched MMP7 (Matrilysin-deficient) mice were infected via the oral route with a 1∶1 mixture of WT and WT <i>S.</i> Typhimurium, or WT and <i>ΔpmrF S</i>. Typhimurium containing 10⁸ CFU of each strain. Graphed values represent the competitive index (CI) ratio output ratio/input ratio) of WT/WT (A.) or Δ<i>pmrF/</i>WT (B.) recovered from the livers and spleens of MMP7 KO mice or C57BL/6 mice at 96 hrs. p.i. Each value graphed as the same shape represents the CI ratio calculated from the specified organ of one WT or MMP7 KO mouse. There are no significant differences between any of the observed average CI ratios (p≥0.05).