Neutralizing antibodies against EBV-encoded DNA polymerase and dUTPase in EBV subset CFS patients and controls.

Antibodies to Human Herpesviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

Blomberg, Jonas
Rizwan, Muhammad
Bohlin-Wiener, Agnes
Elfaitouri, Amal
Julin, Per
Zachrisson, Olof
Rosén, Anders
Gottfries, Carl-Gerhard

January 2019

Myalgic encephalomyelitis, also referred to as chronic fatigue syndrome (ME/CFS) is a debilitating d...

Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design

Zhen-Yong Keck (6711059)
Brian G. Pierce (204648)
Patrick Lau (615778)
Janine Lu (6711062)
Yong Wang (12837)
Alexander Underwood (6711065)
Rowena A. Bull (207778)
Jannick Prentoe (162323)
Rodrigo Velázquez-Moctezuma (3776023)
Melanie R. Walker (6711068)
Fabio Luciani (207782)
Johnathan D. Guest (6711071)
Catherine Fauvelle (3818317)
Thomas F. Baumert (76854)
Jens Bukh (162343)
Andrew R. Lloyd (207808)
Steven K. H. Foung (171667)

May 2019

Cumulative evidence supports a role for neutralizing antibodies contributing to spontaneous viral cl...

Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray.

Loebel, M.
Eckey, M.
Sotzny, F.
Hahn, E.G.
Bauer, S.
Grabowski, P.
Zerweck, J.
Holenya, P.
Hanitsch, L.G.
Wittke, K.
Borchmann, P.
Rüffer, J.U.
Hiepe, F.
Ruprecht, K.
Behrends, U.
Meindl, C.
Volk, H.D.
Reimer, U.
Scheibenbogen, C.

January 2017

Background: Epstein-Barr-Virus (EBV) plays an important role as trigger or cofactor for various auto...

Antibody to Epstein-Barr Virus Deoxyuridine Triphosphate Nucleotidohydrolase and Deoxyribonucleotide Polymerase in a Chronic Fatigue Syndrome Subset

Lerner A. Martin
Ariza Maria E.
Williams Marshall
Jason Leonard
Beqaj Safedin
Fitzgerald James T.
Lemeshow Stanley
Glaser Ronald

November 2012

, and adult rheumatic fever, which may be mistakenly called CFS. CFS patients were treated with vala...

Antibody response to EBV encoded proteins DNA polymerase and dUTPase during treatment with valacyclovir.

A. Martin Lerner (298672)
Maria E. Ariza (288116)
Marshall Williams (59523)
Leonard Jason (298673)
Safedin Beqaj (298674)
James T. Fitzgerald (298675)
Stanley Lemeshow (298676)
Ronald Glaser (203112)

February 2013

Duration of Antibody Response to EBV Encoded Proteins EBV DNA Polymerase and EBV dUTPase During T...

Latent EBV can be detected more frequently in CFS patients.

Madlen Loebel (509600)
Kristin Strohschein (358522)
Carolin Giannini (410906)
Uwe Koelsch (509601)
Sandra Bauer (509602)
Cornelia Doebis (509603)
Sybill Thomas (509604)
Nadine Unterwalder (509605)
Volker von Baehr (509606)
Petra Reinke (373886)
Michael Knops (509607)
Leif G. Hanitsch (509608)
Christian Meisel (46720)
Hans-Dieter Volk (33298)
Carmen Scheibenbogen (358526)

January 2014

(A) EBV DNA was analyzed via nested real-time PCR in total PBMCs of 20 healthy donors and CFS pat...

EBNA antibody response is reduced in CFS patients.

Madlen Loebel (509600)
Kristin Strohschein (358522)
Carolin Giannini (410906)
Uwe Koelsch (509601)
Sandra Bauer (509602)
Cornelia Doebis (509603)
Sybill Thomas (509604)
Nadine Unterwalder (509605)
Volker von Baehr (509606)
Petra Reinke (373886)
Michael Knops (509607)
Leif G. Hanitsch (509608)
Christian Meisel (46720)
Hans-Dieter Volk (33298)
Carmen Scheibenbogen (358526)

January 2014

(A) Serum IgG titers were assessed for healthy controls and CFS patients by ELISA for EBV VCA-IgG...

CFS patients show diminished cytokine response against EBV.

Madlen Loebel (509600)
Kristin Strohschein (358522)
Carolin Giannini (410906)
Uwe Koelsch (509601)
Sandra Bauer (509602)
Cornelia Doebis (509603)
Sybill Thomas (509604)
Nadine Unterwalder (509605)
Volker von Baehr (509606)
Petra Reinke (373886)
Michael Knops (509607)
Leif G. Hanitsch (509608)
Christian Meisel (46720)
Hans-Dieter Volk (33298)
Carmen Scheibenbogen (358526)

January 2014

Whole blood of healthy controls and CFS patients was analyzed by Multiplex-Immunoassay for (A) IF...

Frequency of the presence of the anti-EBV-encoded dUTPase antibody in the patient groups.

Philip F. Binkley (288111)
Glen E. Cooke (288112)
Amanda Lesinski (288113)
Mackenzie Taylor (288114)
Min Chen (147733)
Bryon Laskowski (288115)
W. James Waldman (59521)
Maria E. Ariza (288116)
Marshall V. Williams Jr (288117)
Deborah A. Knight (225781)
Ronald Glaser (203112)

February 2013

Frequency of the presence of the anti-EBV-encoded dUTPase antibody in the patient groups.</p

Patient derived VF-Fab display varying degree of neutralising ability to different E1E2 HCV pseudoparticles.

Amruta S. Naik (4053811)
Ania Owsianka (4053814)
Brendan A. Palmer (3361331)
Ciaran J. O’Halloran (4053820)
Nicole Walsh (4053817)
Orla Crosbie (94761)
Elizabeth Kenny-Walsh (94762)
Arvind H. Patel (33806)
Liam J. Fanning (717762)

May 2017

VF-Fab were purified from antibody-virus complex. VF-Fab1a-1-1, VF-Fab1a-1-2, VF-Fab 1a-1-3 were ...

Nested PCR from the DNA of 8 CFS patients.

Otto Erlwein (345914)
Steve Kaye (46006)
Myra O. McClure (193123)
Jonathan Weber (59115)
Gillian Wills (354882)
David Collier (231300)
Simon Wessely (354884)
Anthony Cleare (354887)

February 2013

Products of generic MLV primers (including XMRV) are shown. Lanes 1–8, CFS patient DNA (2nd<...

EBNA-1-IgG is reduced in a subset of patients but total IgG and B-cell subpopulations are not different in EBNA-1-IgG positive and -negative CFS patients.

Madlen Loebel (509600)
Kristin Strohschein (358522)
Carolin Giannini (410906)
Uwe Koelsch (509601)
Sandra Bauer (509602)
Cornelia Doebis (509603)
Sybill Thomas (509604)
Nadine Unterwalder (509605)
Volker von Baehr (509606)
Petra Reinke (373886)
Michael Knops (509607)
Leif G. Hanitsch (509608)
Christian Meisel (46720)
Hans-Dieter Volk (33298)
Carmen Scheibenbogen (358526)

January 2014

(A) Serum IgG titers were assessed in CFS patients for EBV-IgG and EBV-EBNA-1-IgG (n = 387), (B–E...

Human antibody titers to Epstein–Barr Virus (EBV) gp350 correlate with neutralization of infectivity better than antibody titers to EBV gp42 using a rapid flow cytometry-based EBV neutralization assay

Sashihara, Junji
Burbelo, Peter D.
Savoldo, Barbara
Pierson, Theodore C.
Cohen, Jeffrey I.

September 2009

AbstractMeasurement of neutralizing antibodies to Epstein–Barr virus (EBV) is important for evaluati...

Evidence for the Role of Epstein Barr Virus Infections in the Pathogenesis of Acute Coronary Events

Binkley Philip F.
Cooke Glen E.
Lesinski Amanda
Taylor Mackenzie
Chen Min
Laskowski Bryon
Waldman W. James
Ariza Maria E.
Williams Marshall V.
Knight Deborah A.
Glaser Ronald

January 2013

The role of viral infections in the pathogenesis of atherosclerosis remains controversial largely du...

Stress-associated changes in the steady-state expression of latent Epstein-Barr virus: Implications for chronic fatigue syndrome and cancer

Glaser, R.
Padgett, D. A.
Litsky, M. L.
Baiocchi, R. A.
Yang, E. V.
Chen, M.
Yeh, P. E.
Klimas, Nancy G.
Marshall, G. D.
Whiteside, T.
Herberman, R.
Kiecott-Glaser, J.
Williams, M. V.

March 2005

Antibodies to several Epstein-Barr virus (EBV)-encoded enzymes are observed in patients with differe...

Antibodies to Human Herpesviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

Blomberg, Jonas
Rizwan, Muhammad
Bohlin-Wiener, Agnes
Elfaitouri, Amal
Julin, Per
Zachrisson, Olof
Rosén, Anders
Gottfries, Carl-Gerhard

January 2019

Myalgic encephalomyelitis, also referred to as chronic fatigue syndrome (ME/CFS) is a debilitating d...

Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design

Zhen-Yong Keck (6711059)
Brian G. Pierce (204648)
Patrick Lau (615778)
Janine Lu (6711062)
Yong Wang (12837)
Alexander Underwood (6711065)
Rowena A. Bull (207778)
Jannick Prentoe (162323)
Rodrigo Velázquez-Moctezuma (3776023)
Melanie R. Walker (6711068)
Fabio Luciani (207782)
Johnathan D. Guest (6711071)
Catherine Fauvelle (3818317)
Thomas F. Baumert (76854)
Jens Bukh (162343)
Andrew R. Lloyd (207808)
Steven K. H. Foung (171667)

May 2019

Cumulative evidence supports a role for neutralizing antibodies contributing to spontaneous viral cl...

Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray.

Loebel, M.
Eckey, M.
Sotzny, F.
Hahn, E.G.
Bauer, S.
Grabowski, P.
Zerweck, J.
Holenya, P.
Hanitsch, L.G.
Wittke, K.
Borchmann, P.
Rüffer, J.U.
Hiepe, F.
Ruprecht, K.
Behrends, U.
Meindl, C.
Volk, H.D.
Reimer, U.
Scheibenbogen, C.

January 2017

Background: Epstein-Barr-Virus (EBV) plays an important role as trigger or cofactor for various auto...

Antibody to Epstein-Barr Virus Deoxyuridine Triphosphate Nucleotidohydrolase and Deoxyribonucleotide Polymerase in a Chronic Fatigue Syndrome Subset

Lerner A. Martin
Ariza Maria E.
Williams Marshall
Jason Leonard
Beqaj Safedin
Fitzgerald James T.
Lemeshow Stanley
Glaser Ronald

November 2012

, and adult rheumatic fever, which may be mistakenly called CFS. CFS patients were treated with vala...

Antibody response to EBV encoded proteins DNA polymerase and dUTPase during treatment with valacyclovir.

A. Martin Lerner (298672)
Maria E. Ariza (288116)
Marshall Williams (59523)
Leonard Jason (298673)
Safedin Beqaj (298674)
James T. Fitzgerald (298675)
Stanley Lemeshow (298676)
Ronald Glaser (203112)

February 2013

Duration of Antibody Response to EBV Encoded Proteins EBV DNA Polymerase and EBV dUTPase During T...

Latent EBV can be detected more frequently in CFS patients.

Madlen Loebel (509600)
Kristin Strohschein (358522)
Carolin Giannini (410906)
Uwe Koelsch (509601)
Sandra Bauer (509602)
Cornelia Doebis (509603)
Sybill Thomas (509604)
Nadine Unterwalder (509605)
Volker von Baehr (509606)
Petra Reinke (373886)
Michael Knops (509607)
Leif G. Hanitsch (509608)
Christian Meisel (46720)
Hans-Dieter Volk (33298)
Carmen Scheibenbogen (358526)

January 2014

(A) EBV DNA was analyzed via nested real-time PCR in total PBMCs of 20 healthy donors and CFS pat...

EBNA antibody response is reduced in CFS patients.

Madlen Loebel (509600)
Kristin Strohschein (358522)
Carolin Giannini (410906)
Uwe Koelsch (509601)
Sandra Bauer (509602)
Cornelia Doebis (509603)
Sybill Thomas (509604)
Nadine Unterwalder (509605)
Volker von Baehr (509606)
Petra Reinke (373886)
Michael Knops (509607)
Leif G. Hanitsch (509608)
Christian Meisel (46720)
Hans-Dieter Volk (33298)
Carmen Scheibenbogen (358526)

January 2014

(A) Serum IgG titers were assessed for healthy controls and CFS patients by ELISA for EBV VCA-IgG...

CFS patients show diminished cytokine response against EBV.

Madlen Loebel (509600)
Kristin Strohschein (358522)
Carolin Giannini (410906)
Uwe Koelsch (509601)
Sandra Bauer (509602)
Cornelia Doebis (509603)
Sybill Thomas (509604)
Nadine Unterwalder (509605)
Volker von Baehr (509606)
Petra Reinke (373886)
Michael Knops (509607)
Leif G. Hanitsch (509608)
Christian Meisel (46720)
Hans-Dieter Volk (33298)
Carmen Scheibenbogen (358526)

January 2014

Whole blood of healthy controls and CFS patients was analyzed by Multiplex-Immunoassay for (A) IF...

Frequency of the presence of the anti-EBV-encoded dUTPase antibody in the patient groups.

Philip F. Binkley (288111)
Glen E. Cooke (288112)
Amanda Lesinski (288113)
Mackenzie Taylor (288114)
Min Chen (147733)
Bryon Laskowski (288115)
W. James Waldman (59521)
Maria E. Ariza (288116)
Marshall V. Williams Jr (288117)
Deborah A. Knight (225781)
Ronald Glaser (203112)

February 2013

Frequency of the presence of the anti-EBV-encoded dUTPase antibody in the patient groups.</p

Patient derived VF-Fab display varying degree of neutralising ability to different E1E2 HCV pseudoparticles.

Amruta S. Naik (4053811)
Ania Owsianka (4053814)
Brendan A. Palmer (3361331)
Ciaran J. O’Halloran (4053820)
Nicole Walsh (4053817)
Orla Crosbie (94761)
Elizabeth Kenny-Walsh (94762)
Arvind H. Patel (33806)
Liam J. Fanning (717762)

May 2017

VF-Fab were purified from antibody-virus complex. VF-Fab1a-1-1, VF-Fab1a-1-2, VF-Fab 1a-1-3 were ...

Nested PCR from the DNA of 8 CFS patients.

Otto Erlwein (345914)
Steve Kaye (46006)
Myra O. McClure (193123)
Jonathan Weber (59115)
Gillian Wills (354882)
David Collier (231300)
Simon Wessely (354884)
Anthony Cleare (354887)

February 2013

Products of generic MLV primers (including XMRV) are shown. Lanes 1–8, CFS patient DNA (2nd<...

EBNA-1-IgG is reduced in a subset of patients but total IgG and B-cell subpopulations are not different in EBNA-1-IgG positive and -negative CFS patients.

Madlen Loebel (509600)
Kristin Strohschein (358522)
Carolin Giannini (410906)
Uwe Koelsch (509601)
Sandra Bauer (509602)
Cornelia Doebis (509603)
Sybill Thomas (509604)
Nadine Unterwalder (509605)
Volker von Baehr (509606)
Petra Reinke (373886)
Michael Knops (509607)
Leif G. Hanitsch (509608)
Christian Meisel (46720)
Hans-Dieter Volk (33298)
Carmen Scheibenbogen (358526)

January 2014

(A) Serum IgG titers were assessed in CFS patients for EBV-IgG and EBV-EBNA-1-IgG (n = 387), (B–E...

Human antibody titers to Epstein–Barr Virus (EBV) gp350 correlate with neutralization of infectivity better than antibody titers to EBV gp42 using a rapid flow cytometry-based EBV neutralization assay

Sashihara, Junji
Burbelo, Peter D.
Savoldo, Barbara
Pierson, Theodore C.
Cohen, Jeffrey I.

September 2009

AbstractMeasurement of neutralizing antibodies to Epstein–Barr virus (EBV) is important for evaluati...

Evidence for the Role of Epstein Barr Virus Infections in the Pathogenesis of Acute Coronary Events

Binkley Philip F.
Cooke Glen E.
Lesinski Amanda
Taylor Mackenzie
Chen Min
Laskowski Bryon
Waldman W. James
Ariza Maria E.
Williams Marshall V.
Knight Deborah A.
Glaser Ronald

January 2013

The role of viral infections in the pathogenesis of atherosclerosis remains controversial largely du...

Stress-associated changes in the steady-state expression of latent Epstein-Barr virus: Implications for chronic fatigue syndrome and cancer

Glaser, R.
Padgett, D. A.
Litsky, M. L.
Baiocchi, R. A.
Yang, E. V.
Chen, M.
Yeh, P. E.
Klimas, Nancy G.
Marshall, G. D.
Whiteside, T.
Herberman, R.
Kiecott-Glaser, J.
Williams, M. V.

March 2005

Antibodies to several Epstein-Barr virus (EBV)-encoded enzymes are observed in patients with differe...

Antibodies to Human Herpesviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

Blomberg, Jonas
Rizwan, Muhammad
Bohlin-Wiener, Agnes
Elfaitouri, Amal
Julin, Per
Zachrisson, Olof
Rosén, Anders
Gottfries, Carl-Gerhard

January 2019

Myalgic encephalomyelitis, also referred to as chronic fatigue syndrome (ME/CFS) is a debilitating d...

Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design

Zhen-Yong Keck (6711059)
Brian G. Pierce (204648)
Patrick Lau (615778)
Janine Lu (6711062)
Yong Wang (12837)
Alexander Underwood (6711065)
Rowena A. Bull (207778)
Jannick Prentoe (162323)
Rodrigo Velázquez-Moctezuma (3776023)
Melanie R. Walker (6711068)
Fabio Luciani (207782)
Johnathan D. Guest (6711071)
Catherine Fauvelle (3818317)
Thomas F. Baumert (76854)
Jens Bukh (162343)
Andrew R. Lloyd (207808)
Steven K. H. Foung (171667)

May 2019

Cumulative evidence supports a role for neutralizing antibodies contributing to spontaneous viral cl...

Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray.

Loebel, M.
Eckey, M.
Sotzny, F.
Hahn, E.G.
Bauer, S.
Grabowski, P.
Zerweck, J.
Holenya, P.
Hanitsch, L.G.
Wittke, K.
Borchmann, P.
Rüffer, J.U.
Hiepe, F.
Ruprecht, K.
Behrends, U.
Meindl, C.
Volk, H.D.
Reimer, U.
Scheibenbogen, C.

January 2017

Background: Epstein-Barr-Virus (EBV) plays an important role as trigger or cofactor for various auto...

Neutralizing antibodies against EBV-encoded DNA polymerase and dUTPase in EBV subset CFS patients and controls.

Abstract

Extracted data

Neutralizing antibodies against EBV-encoded DNA polymerase and dUTPase in EBV subset CFS patients and controls.

Abstract

Extracted data

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