KiSS-1 and GPR54 mRNA expression in early-onset and late-onset pre-eclamptic placenta.

<p>Quantitative RT-PCR analysis of KiSS-1 and GPR54 mRNA expressions in preeclamptic (early-onset and late-onset) pregnancies compared with the respective matched control groups. The results demonstrated a significant up-regulation of KiSS-1 transcripts in the placenta of the early-onset preeclamptic pregnancies (A) and not significant difference between the late-onset preeclamptic (B) and control pregnancies. The transcript level of the KiSS-1 was significantly higher in early-onset placenta compared with late-onset preeclampsia (C). GPR54 revealed no significant difference in expression between early-onset/late-onset preeclamptic placenta and controls. Data represent means±SD after normalization to β-actin. *P<0.05, significantly decreased/increased compared with the respective control.