Inhibitory effect of BAY 60-2770 and sodium nitroprusside (SNP) on human platelet adhesion to fibrinogen-coated plates.

<p>Platelets (1.2×10⁸ platelets/ml) were pre-incubated or not with ODQ (10 µM, 3 min) and subsequently with BAY 60-2770 (0.1–10 µM) or SNP (3 µM). Platelets were allowed to adhere to the wells for 30 min at 37°C. Note that 1% DMSO (vehicle used for BAY 60-2770 and ODQ) had no effect on platelet adhesion. Data are shown as percent of adhered platelets relative to the maximum adhesion in untreated platelets. Results are shown as mean ± SEM values (n = 4–6 individuals, each performed in triplicate). *p<0.05 compared with control values (in absence of BAY 60-2770 or SNP). #p<0.05 compared with respective values in absence of ODQ.