<p>The domain boundaries follow Joerger and Fersht 2008 (2). The residues that form hydrogen bonds directly with DNA are shown (9). The lower portion is the crystal structure of p53DBD(94–312)-DNA complex, PDB code 1TUP. The N-terminal region (91–95) determined by X-ray crystallography of p53(89–293), 2XWR (7), is aligned and overlaid.</p
p53 is a tumor suppressor protein activated during DNA damage and cell stress that plays a central r...
p53 is well-known as a tumor suppressor or genome guardian. It is a transcription factor composed of...
The p53 protein is a transcription factor that acts as the major tumor suppressor in mammals. The co...
<div><p>(A) The primary sequence of p53 comprising 393 amino acid residues was retrieved from Unipro...
<p>(A) Schematic view of the domain structure of p53. The 393-residue p53 protein comprises an N-ter...
The tumor suppressor p53 regulates downstream genes in response to many cellular stresses and is fre...
The homotetrameric tumor suppressor p53 consists of folded core and tetramerization domains, linked ...
AbstractThe tetrameric tumor suppressor p53 plays a pivotal role in the control of the cell cycle an...
The identification of many homologs and paralogs of the most famous tumor suppressor, p53, has expan...
The p53 tumor suppressor is widely found to be mutated in human cancer. This protein is regarded as ...
The p53 tumor suppressor is widely found to be mutated in human cancer. This protein is regarded as ...
The p53 tumor suppressor protein is an important molecule studied extensively in cancer research. In...
<p>The C-terminal domain contains the folded tetramerization domain (red) flanked by two unfolded do...
The p53 tumor suppressor plays a crucial role in maintaining the integrity of the genome by triggeri...
The p53 tumor suppressor plays a crucial role in maintaining the integrity of the genome by triggeri...
p53 is a tumor suppressor protein activated during DNA damage and cell stress that plays a central r...
p53 is well-known as a tumor suppressor or genome guardian. It is a transcription factor composed of...
The p53 protein is a transcription factor that acts as the major tumor suppressor in mammals. The co...
<div><p>(A) The primary sequence of p53 comprising 393 amino acid residues was retrieved from Unipro...
<p>(A) Schematic view of the domain structure of p53. The 393-residue p53 protein comprises an N-ter...
The tumor suppressor p53 regulates downstream genes in response to many cellular stresses and is fre...
The homotetrameric tumor suppressor p53 consists of folded core and tetramerization domains, linked ...
AbstractThe tetrameric tumor suppressor p53 plays a pivotal role in the control of the cell cycle an...
The identification of many homologs and paralogs of the most famous tumor suppressor, p53, has expan...
The p53 tumor suppressor is widely found to be mutated in human cancer. This protein is regarded as ...
The p53 tumor suppressor is widely found to be mutated in human cancer. This protein is regarded as ...
The p53 tumor suppressor protein is an important molecule studied extensively in cancer research. In...
<p>The C-terminal domain contains the folded tetramerization domain (red) flanked by two unfolded do...
The p53 tumor suppressor plays a crucial role in maintaining the integrity of the genome by triggeri...
The p53 tumor suppressor plays a crucial role in maintaining the integrity of the genome by triggeri...
p53 is a tumor suppressor protein activated during DNA damage and cell stress that plays a central r...
p53 is well-known as a tumor suppressor or genome guardian. It is a transcription factor composed of...
The p53 protein is a transcription factor that acts as the major tumor suppressor in mammals. The co...
DOI
Add to ORKG