P44 nuclear translocation is associated with the decrease in cell proliferation during prostate development.

<p>(A) Proliferation rate of prostate epithelial cells is decreased during mouse development. BrdU was injected into mice, and 3 days later, inmmunostaining with anti-BrdU antibody was performed on the anterior (AP) and dorsal lateral (DLP) prostates to identify BrdU-positive (proliferating) prostate epithelial cells (in brown). (B) The quantitative data of proliferative epithelial cells in the AP or DLP prostate are shown. Numbers in parentheses indicate the percentages of BrdU-positive epithelial cells. One-way ANOVA analysis: F = 873.4, p<0.0001, R square = 0.9976. The p values of unpaired Student’s t-Test of data between 7–10 d and 14–17 d and between 30 d and 60 d are <0.0001 and 0.0060, respectively.