Generative models are too null.

<p>Panel (a): Quantile plot of Meme E-values for approximately 15,000 random runs, with E-values excluded. The X-axis represents the E-value as reported by MEME. The Y-axis represents the quantile. For example, under our null model E-values below are reported with probability slightly more than . Panels (b) and (c): Quantile plots of LR false discovery rates, similar to the Meme E-value quantile plots, for the Beer et al. and Human Cmap datasets respectively. Panel (d): Z-score plots of A/T fraction of yeast and human intergenic sequences relative to the distribution expected under a 6th order Markov model, with the standard normal distribution (red) shown for reference.