Gastric epithelial differentiation is significantly altered by <i>Fgf10</i> overexpression during homeostasis.

<p>Immunostaining for markers of terminally differentiated gastric epithelial cells of sections of adult glandular stomach in control littermate (<i>R26^rtTA/+; tet(O)Fgf10/+</i> without dox) (A,D,G,J) and mutant <i>Fgf10</i> overexpressing mice (<i>R26^rtTA/+; tet(O)Fgf10/+</i> with dox) (B,E,H,K). (A-B) Mucous neck cells are identified by GSII and (C) quantification reveals a significant increase in mutant <i>Fgf10</i> overexpressing mice compared to control littermates (*p<0.05). (D,E) Chief cells are marked by intrinsic factor and (F) quantification shows a significant decrease in chief cell number (*p<0.05). (G,H) Endocrine cells are identified by chromogranin A and (I) quantification demonstrates no significant change in endocrine cell number. (J,K) Parietal cells are visualized with H/K ATPase immunostaining and (L) quantification demonstrates a significant reduction in mutant <i>Fgf10</i> overexpressing mice compared to control littermates (*p<0.05). Dox was given for 10 days. The scale bar is 50 µm. GE = gastric epithelium, L = lumen.