FGF10-FGFR2b mediated signaling is not required for gastric epithelial differentiation during homeostasis.

<p>Mucous neck cells are marked by GSII immunostaining of sections of adult glandular stomach in control littermate (<i>R26^+/+; tet(O)sFgfr2b/+</i>with dox) (A) and mutant mice (<i>R26^rtTA/+; tet(O)sFgfr2b/+</i> with dox) (B) and (C) quantification reveals no difference in mucous neck cell number. Chief cells are identified by intrinsic factor immunostaining of sections of adult glandular stomach in control littermate (<i>R26^+/+; tet(O)sFgfr2b/+</i> with dox) (D) and mutant mice (<i>R26^rtTA/+; tet(O)sFgfr2b/+</i> with dox) (E) and (F) quantification reveals no significant change in chief cell number. (G,H) Endocrine cells are identified by chromogranin A and (I) quantification shows no significant change in mutant <i>sFgfr2b</i> overexpressing mice compared to control littermates. Parietal cells are identified by H/K ATPase immunostaining of sections of adult glandular stomach in control littermate (<i>R26^+/+; tet(O)sFgfr2b/+</i>with dox) (J) and mutant mice (<i>R26^rtTA/+; tet(O)sFgfr2b/+</i> with dox) (K) and (L) quantification reveals no significant change in parietal cell number. Dox was given for 1 month. The scale bar is 50 µm. GE = gastric epithelium, L = lumen.