Serum antibody responses following mucosal vaccination.

<p>Animals (n = 6 per group) were vaccinated i.t. (panel A) or orally (panel B) with either 10⁵ CFU U112, 10⁷ CFU U112Δ<i>iglB</i>, or mock vaccinated with PBS and rested for 28 days. Serum was analyzed by ELISA to obtain 50% binding titers. Titers from both vaccinated groups, regardless of route, were shown to be significant compared to mock (**<i>p</i><0.001, *<i>p</i><0.01). <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0047639#s3" target="_blank">Results</a> are representative of two independent experiments.