Glutathione redox status in hippocampi of mice undergoing 2- or 4-mo moderate treadmill running.

<p>Evaluation of the glutathione redox balance in hippocampi of mature CD1 female mice undergoing a two- or four-month moderate and regular treadmill-based exercise program (E2 or E4, respectively); age-matched sedentary animals (S2, S4) were used as controls (n = 12 per group). A significant age-dependent decrease in the total vs oxidized glutathione ratio was found within mouse hippocampal formations (S4 vs S2). 2-mo running decreased the total vs disulfide glutathione ratio (E2 vs S2), whereas no significant change was induced by 4-mo exercise (E4 vs S4). Values were given as means ± std. dev. The level of statistical significance was computed by using two-way ANOVA and post-hoc Newman-Keuls test: *** P<0.001; ** P<0.01. Experiments were performed in triplicate.