Self administration of sucrose/ethanol solution remains unchanged in GABA_A α2-subunit KO mice.

<p>(<b>A</b>) Sessions to criteria<b>.</b> The genotypes did not differ in their acquisition of self administration, performing a similar number of sessions to criteria at each concentration of ethanol (n = 8; 10%0%: U = 31.5, p = 0.648; 10%3%: U = 28.0, p = 1.00; 10%5%: U = 22.5, p = 0.448; 7%5%: U = 27.5, p = 0.951; 10%10%: U = 28.0, p = 1.00) (<b>B</b>) Number of active lever presses. Both genotypes perform a comparable number of lever presses to obtain increasing concentrations of ethanol in a sucrose/ethanol solution (genotype by reinforcer interaction, F_(4,52) = 0.721, p = 0.486, ε = 0.462) (<b>C</b>) Number of reinforcers earned. Both WT and KO mice earned a similar number of reinforcers at each concentration of ethanol (genotype by reinforcer interaction, F_(4,52) = 0.486, p = 0.604, ε = 0.456), indicating that motivation to obtain ethanol is unchanged after a deletion of the GABA_A α2-subunit.